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KMID : 0357920120460010068
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Korean Journal of Pathology
2012 Volume.46 No. 1 p.68 ~ p.74
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Evaluation of Urine Cytology in Urothelial Carcinoma Patients: A Comparison of CellprepPlus® Liquid-Based Cytology and Conventional Smear
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Son Seung-Myoung
Koo Ji-Hae
Choi Song-Yi
Lee Ho-Chang
Lee Yong-Moon
Song Hyung-Geun
Hwang Hae-Kyung
Han Hye-Suk
Yun Seok-Joong
Kim Wun-Jae
Kim Eun-Joong
Lee Ok-Jun
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Abstract
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Background: Urine cytology is an important test in the screening of urothlelial neoplasms. The conventional smear (CS) method of testing urine samples has a low sensitivity, approximately 50% result accuracy for detecting urothelial carcinomas, while liquid-based cytology (LBC) has much improved diagnostic accuracy, sensitivity, and specificity. The aim of this study was to compare the morphologic features and diagnostic efficacy of CellprepPlus® LBC with those of CS for urine cytology.
Methods: A total of 713 cases of urine specimens collected from November 2009 to September 2010 were included. All specimens were divided equally for the preparation of CellprepPlus ® LBC and CS for each case.
Results: CellprepPlus® revealed more cellularity, a cleaner background and better cytomorphologic features, but it showed a less intact architectural pattern compared to that of CS. Of the 88 histologically confirmed cases, the diagnostic sensitivity for CellprepPlus® was 50% and higher than the 37.5% for CS. The specificity of both preparations was 100%.
Conclusions: The CellprepPlus® showed an improved quality of slides and provided better diagnostic accuracy, thus CellprepPlus® could be a first-line screening tool in urinary tract cytology.
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KEYWORD
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Carcinoma, urothelial, Urine, cytology, Urinary bladder neoplasms
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